By E. Leuchars (auth.), Dr. Dudley Cohen Dumonde (eds.)
This quantity includes papers offered at a symposium on "The function of Lympho cytes and Macrophages within the Immunological reaction" on the XIII foreign Congress of Haematology, Munich, August 1970. This symposium was once designed to spotlight present paintings submitted to the Haemato logy Congress which with regards to the function of mobile cooperation in induction and expression of the immune reaction. The symposium used to be divided into elements. The morning consultation consisted of invited papers facing a number of normal points of the sector (papers 1 to five) that have been suitable to the afternoon consultation, which con sisted of loose communications submitted to the Congress. within the dialogue it used to be emphasised that while lymphocyte task finally underlies all immune induction, the mobile and humoral manifestations of the immune reaction are ruled by way of certain but interacting cubicles of the ly.mphoid method. a lot curiosity focused at the position of thymus-derived lymphocytes as cooperator cells in antibody formation; and the mechanisms through which macro phages support antibody creation. The dialogue introduced jointly paintings on lympho cyte activation, the iteration of lymphocyte activation items (lymphokine components) and the mobile occasions underlying the induction and expression of the Immune reaction. The priceless cooperation of Springer-Verlag has enabled quick ebook of the papers awarded at this symposium. London, February 1971 D. C. DUMONDE Symposium Moderator Contents The Spectrum of Thymus Dependency. E. LEUCHARS 1 The movement of knowledge in the course of fundamental Antibody Synthesis. D. ]ACHERTS.
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Extra resources for The Role of Lymphocytes and Macrophages in the Immunological Response: XIII International Congress of Haematology, Munich, August 2–8, 1970
N. I. H. Workshop on methods in cell-mediated immunity, New York 1970. : B. BLOOM. In press (1970b). The Uptake of Antigens and Non-Antigenic Markers by Mouse Spleen and Peritoneal Cells~': T. MANDEL and P. BYRT With 3 Figures The initial events in the induction of an immune response are poorly understood but it is generally believed that a response is initiated when antigens react with receptors located on the surface of lymphoid cells. It is also believed that these receptors are immunoglobulin molecules and recent work suggests that they may be IgM molecules .
On the other hand, they might increase the sensitivity of the precursor cells or assist proliferation of clones of antibody-producing cells. Table 1 Non-attached cells Q8Xl~ Attached cells (2XI06) Supernatant medium of attached cells 10 I~Xl~ 5Xl~ o 120 1400 1570 o 91 25 258 280 PFCjculture Table 2 Non-attached cells Peritoneal exudate cells PFCjl0 6jday 5 4XI0 6 4XI0 6 4XI0 6 4XI0 6 4XI06 4XI06 2XI04 6XI0 4 lXI05 2XI05 8XI05 54 53 326 2500 2170 90 Cell Fractionation Using Bovine Serum Albumin (BSA) Gradients Fractionation of spleen cells was undertaken in BSA [6, 7] and Ficoll  gradients.
Proc. Soc. expo Biol. ) 122, 167 (1966). 10. MILLER. J. F. A. , MITCHELL, G. : J. expo Med. 128, 801 (1968). 11. HIRST, j. , DUTTON, R. : Cellular Immunology, in press. 12. , HUNTER. : Nature 255, 277 (1970). 13. : Nature 226, 1258 (1970). Lymphocyte Mitogenic Factor in Cell-Mediated Immunity R. A. WOLSTENCROFT, M. MATTHEW, C. OATES, R. N. MAINI, and D. C. DUMONDE With 2 Figures Introduction One of the most striking recent advances in immunobiology is the recognition that immune induction is regulated by cellular interactions between physiologically distinct compartments of the lymphoid system (for refs.
The Role of Lymphocytes and Macrophages in the Immunological Response: XIII International Congress of Haematology, Munich, August 2–8, 1970 by E. Leuchars (auth.), Dr. Dudley Cohen Dumonde (eds.)