E Nieschlag; H M Behre; S Nieschlag's Testosterone : action, deficiency, substitution PDF

By E Nieschlag; H M Behre; S Nieschlag

ISBN-10: 1107012902

ISBN-13: 9781107012905

Now in its fourth variation Testosterone: motion, Deficiency, Substitution presents the main updated and finished resource of data on testosterone and its function in human body structure and pathology. It covers biosynthesis and mechanisms of motion and experiences their results on mind and behaviour, spermatogenesis, hair progress, bones, muscle tissues, erythropoiesis, the cardiovascular procedure and the prostate. The healing makes use of of testosterone arrangements are rigorously evaluated in addition to its abuse and detection in aggressive recreation. This re-creation additionally devotes sections to exploring the consequences of testosterone on woman body structure and sexual functionality, and the experimental use of testosterone in male hormonal birth control. Testosterone: motion, Deficiency, Substitution has been written and edited by way of global specialists within the fields of scientific andrology and endocrinology and offers a different and necessary consultant for andrologists, endocrinologists, urologists, internists and people operating in reproductive drugs

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Additional resources for Testosterone : action, deficiency, substitution

Example text

Chapter 2: Biosynthesis, transport, metabolism and actions The regulation of androgen receptor expression at the transcriptional and translational level is complex and depends on factors such as age, cell type and tissue. Generally, androgens have a positive effect on stabilization of the receptor protein, so that androgen administration leads to inhibition of receptor degradation and thereby to an increase in androgen receptor protein levels. The effects of androgens on the androgen receptor mRNA are the opposite.

Bose M, Whittal RM, Miller WL, Bose HS (2008) Steroidogenic activity of StAR requires contact with mitochondrial VDAC1 and phosphate carrier protein. J Biol Chem 283:8837–8845 Canto P, Soderlund D, Ramon G, Nishimura E, Mendez JP (2002) Mutational analysis of the luteinizing hormone receptor gene in two individuals with Leydig cell tumors. Am J Med Genet 108:148–152 Castoria G, Lombardi M, Barone MV, Bilancio A, Di Domenico M, Bottero D, Vitale F, Migliaccio A, Auricchio F (2003) Androgenstimulated DNA synthesis and cytoskeletal changes in fibroblasts by a nontranscriptional receptor action.

Testosterone concentrations in the testicular lymphatic circulation and in the venous blood are very similar, but there are essential differences in the flow rate and velocity of both systems. Therefore, Chapter 2: Biosynthesis, transport, metabolism and actions transport of testosterone in the general blood circulation occurs mainly through the spermatic vein. Androgens diffuse into interstitial fluid and then enter testicular capillaries or enter capillaries directly from Leydig cells that are in direct contact with the testicular microvasculature.

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Testosterone : action, deficiency, substitution by E Nieschlag; H M Behre; S Nieschlag


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