New PDF release: Smallpox - A Medical Dictionary, Bibliography, and Annotated

By Health Publica Icon Health Publications

ISBN-10: 0585481679

ISBN-13: 9780585481678

ISBN-10: 0597836078

ISBN-13: 9780597836077

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The polynucleotide vaccine delivery system described here uses a microneedle array with the polynucleotide coated right on the needle in the array. 15 mm long. This array in inserted into the skin with the needle penetrating to about the basal lamina. After insertion the polynucleotide leaves the needle surface and an electric field is used to permeabilize dendritic and epithelial cell membranes to permit the polynucleotide to enter the cell. The system will be tested with the WRAIR/Cyto Pulse dengue DNA vaccine which will be used as a model for hemorrhagic fever viruses and the USAMRIID vaccinia DNA plasmid which is the primary vaccine for small pox.

Subsequently, the function of candidate host proteins will be abrogated to determine whether viral biogenesis is affected. These efforts will likely not only provide a better understanding of how the virus interacts with its host during replication, but also suggest novel biochemical targets in the future rational design of therapeutic intervention against poxviruses. Generate_Screen • Project Title: HOST RESPONSES TO SMALLPOX AND MONKEYPOX Principal Investigator & Institution: Relman, David A.

Pestis) will also be evaluated after proof of concept is achieved with the optimal adjuvant-delivery system combination for rPA. These efforts meet the near term needs for more effective and safer biodefense vaccines and set the foundation for improved innate immune-based therapies of the future through our SMIP design and discovery program. Generate_Screen • Project Title: NOVEL TARGETS FOR TREATMENT OF SMALLPOX Principal Investigator & Institution: Shuman, Stewart H. Professor; Sloan-Kettering Institute for Cancer Res New York, NY 10021 Timing: Fiscal Year 2002; Project Start 15-SEP-2002; Project End 31-AUG-2004 Summary: (provided by applicant): The goal of this project is to identify novel targets and drugs for the treatment and prophylaxis of smallpox.

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Smallpox - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by Health Publica Icon Health Publications


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