Get Receptors as Supramolecular Entities PDF

By Giovanni Biggio

ISBN-10: 0080298044

ISBN-13: 9780080298047

This quantity bargains a wide ranging view of the strategies which are being elaborated to arrive a greater figuring out of the functionality of the receptors for crucial neurotransmitters operative within the mind. Receptor functionality is studied dynamically utilizing transducer functionality measurements, alterations in coupling potency in the course of version and drug motion, and measurements of kinetic parameter for the binding of fundamental transmitter and cotransmitters to precise detectors

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The f u n c t i o n o f t h e D-3 s i t e s i s u n c l e a r . , 1976) o r a n t i - P a r k i n s o n i a n ( T i t e l e r and Seeman, 1978) p o t e n c i e s n o r do t h e y c o r r e s p o n d w e l l w i t h a b i l i t y t o b l o c k s t i m u l a t i o n o f dopami n e - s e n s i t i ve a d e n y l a t e c y c l a s e . Lesion s t u d i e s s u g g e s t t h a t t h e D-3 s i t e may r e p r e s e n t a u t o r e c e p t o r s on n i g r o - s t r i a t a l t e r m ­ i n a l s ( v i de i n f r a ) .

Some o f the biochemical mechanisms i n v o l v e d in the dopaminergic r e g u l a t i o n o f hormone r e l e a s e have been b e t t e r e l u c i d a t e d in the i n t e r m e d i a t e p i t u i t a r y . I t is known t h a t the i n t e r m e d i a t e p i t u i t a r y is p r e d o m i n a n t l y composed o f c o r t i cotrophi c eel Is which s y n t h e s i z e and s e c r e t e a v a r i e t y o f p e p t i d e s r e l a t e d to b e t a - 1 i p o t r o p i n and ACTH, i n c l u d i n g b e t a - e n d o r p h i n and alpha-MSH.

26 I. Creese et al. A s i n g l e e x p l a n a t i o n o f t h e s e t h r e e common, n o n - a d d i t i v e e f f e c t s o f h e a t t r e a t m e n t and g u a n i n e n u c l e o t i d e s i s s u g g e s t e d by t h e c h a r a c t e r i z a t i o n o f a GTP-binding r e g u l a t o r y p r o t e i n ("N") t h a t modulates beta a d r e n e r g i c r e c e p t o r f u n c t i o n (Ross and G i l m a n , 1 9 8 0 ) . T h i s p r o t e i n , when c o u p l e d w i t h t h e b e t a r e c e p t o r - and p o s s i b l y many o t h e r n e u r o t r a n s m i t t e r and hormones r e c e p t o r s ( R o d b e l l , 1980) - e n a b l e s h i g h a f f i n i t y b i n d i n g o f / " 3 H 7 a g o n i s t 1 i gands and When N / r e c e p t o r a s s o c i a ­ p o t e n t d i s p l a c e m e n t o f /" 3 H7antagoni s t s by a g o n i s t s .

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Receptors as Supramolecular Entities by Giovanni Biggio


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