Download e-book for iPad: Potassium Channels And Their Modulators From Synthesis To by John M Evans

By John M Evans

ISBN-10: 0748405577

ISBN-13: 9780748405572

Potassium ions okay+ ions are very important in physiological strategies, quite with reference to the cardiovascular procedure. Modulators impression the channels during which those ions circulation and the learn into modulator medicines of those channels is the topic of rapidly-advancing study. This paintings is meant to be of use as a device for these operating within the pharmaceutical undefined. Early chapters pay attention to the synthesis and structure-activity relationships of potassium channel modulators. those are by way of dialogue at the software of those medicinal drugs to varied goal organs, resembling the cardiovascular approach and the airlines. The booklet concludes with a wide assessment of scientific event and destiny prospects.; The authors convey how potassium channel activators and potassium channel blockers each one have a job to play as healing brokers for lots of problems, together with bronchial asthma and respiration tract problems, ailments of the critical frightened procedure comparable to epilepsy, and vascular illnesses resembling angina, peripheral vascular affliction and hypertension. This booklet should still for this reason even be of curiosity to these discovering into this wide variety of ailments.

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BLARER, S. (1988) Circ. , 62, 679–686. V. L. , 30, 3349–3350. , MARSH, A. L. (1989) Chem. , 1258–1259. , SATO, T. & NABATA, H. (1993) BioMed. Chem. , 3, 1659–1662. R. & DENG, L. (1991) J. Am. Chem. , 113, 7063–7064. J. (1978) Synthesis, 886–887. , HOSOYA, N. & HATAYAMA, A. (1992) Patent to Nissan Chemical Industries Ltd. EP 535377. , ISHIZAWA, T. & NABATA, H. (1993a) BioMed. Chem. , 3, 625–631. , NABATA, H. S. & SUGO, I. (1993b) BioMed. , 3, 1111–1114. , SATO, T. & NABATA, H. (1993c) BioMed. Chem.

LUES, I. (1990b) Patent to E. Merck DE 3840011. BERGMANN, R. & GERICKE, R. (1990) J. Med. , 33,492–504. , EIERMANN, V. & GERICKE, R. (1990) J. Med. , 33, 2759–2767. , WEINBERGER, J. H. H. P. 405298. BLARER, S. (1988) Patent to Sandoz Ltd. GB 2204868. R. F. (1993) Br. J. , 109, 1133–1139. R. G. (1993) Curr. Top. Med. , 1, 291–311. G. M. (1990) J. Med. , 33, 3028–3034. M. B. (1991a) J. Med. , 34, 919–926. G. M. C. S. Perkin Trans. 1, 63–70. G. B. C. S. Perkin Trans. 1, 2763–2771. L. G. , 33, 1109–1112.

THOM, E. (1972) J. Org. , 37, 841–848. S. & BLARER, S. (1988) Circ. , 62, 679–686. V. L. , 30, 3349–3350. , MARSH, A. L. (1989) Chem. , 1258–1259. , SATO, T. & NABATA, H. (1993) BioMed. Chem. , 3, 1659–1662. R. & DENG, L. (1991) J. Am. Chem. , 113, 7063–7064. J. (1978) Synthesis, 886–887. , HOSOYA, N. & HATAYAMA, A. (1992) Patent to Nissan Chemical Industries Ltd. EP 535377. , ISHIZAWA, T. & NABATA, H. (1993a) BioMed. Chem. , 3, 625–631. , NABATA, H. S. & SUGO, I. (1993b) BioMed. , 3, 1111–1114.

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Potassium Channels And Their Modulators From Synthesis To Clinical Experience by John M Evans


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