Read e-book online Notch Regulation of the Immune System PDF

By Anna Bigas, Teresa D’Altri, Lluis Espinosa (auth.), Freddy Radtke (eds.)

ISBN-10: 3642242936

ISBN-13: 9783642242939

ISBN-10: 3642242944

ISBN-13: 9783642242946

Notch signaling regulates many mobilephone destiny choice and differentiation strategies in the course of embryonic improvement and tissue homeostasis. in addition, disregulation of the pathway is linked to human problems and melanoma. within the final 15 years it grew to become obvious that Notch performs very important roles within the hematopoietic process in addition to within the legislation of immune responses. This unique factor on Notch rules of the immune process summarizes contemporary advances and covers a number of facets of Notch signaling in the hematopoietic and the immune approach. This factor covers matters together with Notch functionality in embryonic and grownup hematopoietic stem cells, lymphocyte improvement and serve as in addition to in T phone leukemia.

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2008). Furthermore, overexpression of ADAM10 in early lymphocyte progenitors under the H-2 Kb promoter and the IgH enhancer region, exhibited a smaller thymus, reduced DN and DP thymocyte populations and other B and myeloid specific defects (Gibb et al. 2011). In contrast, proteolytic processing of Notch ligands is not critical during T cell development. Using an uncleavable Dll1 overexpressed in OP9 cells, T cell development was analyzed and found to progress normally (Gravano and Manilay 2010).

Dev Dyn 235:886–894 Ciofani M, Zuniga-Pflucker JC (2005) Notch promotes survival of pre-T cells at the betaselection checkpoint by regulating cellular metabolism. Nat Immunol 6:881–888 Ciofani M, Zuniga-Pflucker JC (2007) The thymus as an inductive site for T lymphopoiesis. Annu Rev Cell Dev Biol 23:463–493 Notch Receptor-Ligand Interactions During T Cell Development 39 Ciofani M, Schmitt TM, Ciofani A, Michie AM, Cuburu N, Aublin A, Maryanski JL, Zuniga-Pflucker JC (2004) Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation.

This force would presumably have to be created in the signal-sending cell and involve other proteins, such as Epsin, Dynamin, and Clathrin, which have all been implicated in generating a mechanical force (Liu et al. 2010; McMahon and Gallop 2005) and shown to have a role in Notch ligand endocytosis. Notch receptor 30 D. K. Shah and J. C. Zúñiga-Pflücker binding to ligand induces ubiquitinylation of the Notch ligand, and recruitment of Epsin (Overstreet et al. 2004; Tian et al. 2004; Wang and Struhl 2004).

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Notch Regulation of the Immune System by Anna Bigas, Teresa D’Altri, Lluis Espinosa (auth.), Freddy Radtke (eds.)


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