By Paolo Montuschi
Exhaled breath condensate is a brand new, non-invasive approach for sampling secretions from the airlines. New views in tracking of Lung irritation presents an creation to the research of exhaled breath condensate for tracking lung irritation. The publication offers present wisdom at the physicochemical homes of exhaled breath condensate and its formation within the airlines and covers very important points of the method. It information markers, or periods of markers, of airway irritation in separate chapters and discusses using the procedure in adults and kids. the amount concludes with a glance on the implications for drug improvement and destiny examine.
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Extra info for New Perspectives in Monitoring of Lung Inflammation: Analysis of Exhaled Breath Condensate
Increased nitrotyrosine in exhaled breath condensate in cystic fibrosis, Eur. Respir. , 17, 1201, 2001. 66. Gessner, C. , Exhaled breath condensate nitrite and its relation to tidal volume in acute lung injury, Chest, 124, 1046, 2003. fm Page 30 Wednesday, August 25, 2004 4:57 PM 30 New Perspectives in Monitoring Lung Inflammation 67. R. , Increased exhalation of hydrogen peroxide in patients with stable and unstable chronic obstructive pulmonary disease, Am. J. Respir. Crit. , 154, 813, 1996.
Indirect monitoring of lung inflammation, Nat. Rev. , 1, 238, 2002. 11. Montuschi, P. , Analysis of exhaled breath condensate for monitoring airway inflammation, Trends Pharmacol. , 23, 232, 2002. 12. , Expired breath condensate (EBC) and the ultimate disposition of airway surface liquid (ASL), Am. J. Respir. Crit. , 163, A406, 2001. 13. Montuschi, P. , Increased 8-isoprostane, a biomarker of oxidative stress, in exhaled condensate of asthma patients, Am. J. Respir. Crit. , 160, 216, 1999. 14.
Ideally the concentration of R would be the same in the plasma and the fluid covering the respiratory surfaces. Then: D= [ R]resp. 2) where [R] designates the concentrations of the reference indicator in the plasma, respiratory fluid and droplets (“resp”), and the condensate. 3) This equation was based upon the assumptions that (1) the respiratory secretions are isotonic relative to plasma, and (2) the sum of Na+ and K+ (and associated anions) in the condensates represents most of the osmolality of the respiratory fluid and plasma.
New Perspectives in Monitoring of Lung Inflammation: Analysis of Exhaled Breath Condensate by Paolo Montuschi