By N. R. Farnsworth, A. S. Bingel (auth.), Prof. Dr. H. Wagner, Dr. P. Wolff (eds.)
The proven fact that, of the nearly 600,000 plant species present in the world, just some five % were particularly investigated chemically or pharmacologi cally, is a problem to chemists spezializing in na tural elements and to pharmacologists. In view of the restricted variety of learn capacities and the ever diminishing monetary capability, this problem can merely be met if, including an development and refinement of equipment of study, medicinal plant learn is performed on a broader interdisciplinary foundation, with similar, scientifically famous screening equipment, and whether it is higher coordinated, with better use of contemporary documentation capacity. it truly is hence precious sooner or later to pay attention in particular on initiatives resulting in the improvement of latest medicinal prepara tions. The plenary lectures carry within the current symposium of the first foreign Congress for examine on Medi cinal vegetation mirror those efforts and trends. even as they supply a survey of a few of the fields of medicinal plant learn that are at the moment so much genuine and such a lot intensively researched. they vary from plant screening, isolation and constitution eluci dation of latest ideas, to the therapeutical opti mization of a common product. The lectures given at this congress convey basically the need, as well as nationwide phytochemical so cieties, for a relevant foreign organization, during which all energetic medicinal plant researchers on the earth are incorporated. Their goal might be to supply the impulse for extra optimum, rational learn, aimed toward the answer of particular projects.
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While such quantitative studies are clearly publishable, the goal of the hippocratic screen really is not quantitation but qualitative orientation -- to guide the pharmacologist and toxicologist in launching more specific studies (secondary and tertiary evaluations) and to guide the pharmacognosist in extraction/isolation procedures. , 1975). While salicylates and other antiinflammatory agents present recognizable profiles of activity upon hippocratic screening, our laboratory often applies a modified hippocratic/antiinflammatory screen to any crude drug with some suggestion of analgesic and/or antiinflammatory activity in its ethnomedical history.
Only the rat screen requires that all blanks on the work-sheet must be filled in to be sure that some parameter has not been inadvertently overlooked. This requirement (although merely one of procedure) is important in that the absence of symptomatology is virtually as important as the presence of symptomatology in evaluating the data. , 300, and 1000 mg/kg) while the rat version insists on the operator determining the actual doseresponse curve based upon where ineffective and lethal doses occur.
New Natural Products and Plant Drugs with Pharmacological, Biological or Therapeutical Activity: Proceedings of the First International Congress on Medicinal Plant Research, Section A, held at the University of Munich, Germany, September 6–10, 1976 by N. R. Farnsworth, A. S. Bingel (auth.), Prof. Dr. H. Wagner, Dr. P. Wolff (eds.)