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By Hardy G.H., Rogosinski W.W.

Vintage, graduate-level textual content discusses the Fourier sequence in Hilbert area, examines extra homes of trigonometrical Fourier sequence, and concludes with an in depth examine the functions of formerly defined theorems

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1). These last three constructs all contain a deletion of the amino acid residue Ile91, located at the contact interface of the two TM helices (Fig. 2). 1 ), indicating that Ile91 is probably not specifically Table 1. Dimerisation capacity of GpA C-terminal mutants Mutant Sequence Dimer (%) Wt 72EITLIIFGVMAGVIGTILLISYGIRRLIKK1OI 72EITLIIFGVMAGVIGTI---GIRRLIKK1OI 72EITLIIFGVMAGVIGTI --SYGIRRLIKK10l 72EITLIIFGVMAGVIGTILL--GIRRLIKKIOI 72EITLIIFGVMAGVIGTILL-SYGIRRLIKKIOI 72EITLIIFGVMAGVIGTILLLLLGIRRLIKKI01 72EITLIIFGVMAGVIGTILLLLLLLRRLIKK10l 72EITLIIFGVMAGVI GTI --SYGI - LIKK101 72EITLIIFG VMAGVI GTI --SYG ILLLIKK 101 72EITLIIFGVMAGVI GTI --SYG ILLLILL 101 72EITLIIFGVMAGVIGTILL-SYGI - LIKK10l 72EITLIIFGVMAGVIGTILL-SYGILLLIKK1OI 72EITLIIFGVMAGVIGTILLISYGI - LIKK10l 72EITLIIFGVMAGVIGTILLISYGILLLIKK1OI 72EITLIIFGVMAGVIGTILLISYGILLLILL1Ol 84 0 0 9 86 78 77 2 2 73 0 45 69 74 55 1189/93 1189/91 1191/93 1191 91-93L 91-95L 1189/91,1196/97 1189/91,96/97L 1189/91,96/97L,1001101L 1191,1196/97 1191,96/97L 1196/97 96/97L 96/97L,1001101L 6 Mar Orzaez et al.

The hydrocarbon core (He) is the hydrophobic part of the membrane that is approximately 30 A thick. The polar heads of the phospholipids define the lipid/water interphases (IF) and add 15 Ato the thickness of each leaflet. It is this complex environment, with physical and chemical properties different from aqueous media, into which membrane proteins are integrated. All membrane protein structures solved to date show that TM domains fold as either a-helices or ~-strands, due to the physical and chemical constraints imposed by the hydrophobic environment (White and Wimley, 1999).

2001). Proline-induced hinges in transmembrane helices: possible roles in ion channel gating. Proteins 44(2), 63-72 Tomita, M. & Marchesi, V. T. (1975). Amino-acid sequence and oligosaccharide attachment sites of human erythrocyte glycophorin. Proc Natl Acad Sci USA 72(8),2964-8 Ulmschneider, M. B. & Sansom, M. S. (2001). Amino acid distributions in integral membrane protein structures. Biochim Biophys Acta 2( 1), 1-14 von Heijne, G. (1992). ] Mol Bioi 225(2), 487 -494 Wallin, E. & von Heijne, G.

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Fourier Series by Hardy G.H., Rogosinski W.W.


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