Download PDF by David M. Reid (auth.), David M. Reid MBChB, MD, FRCP, Colin: Clinical Trials in Rheumatoid Arthritis and Osteoarthritis

By David M. Reid (auth.), David M. Reid MBChB, MD, FRCP, Colin G. Miller BSc, PhD, FICR (eds.)

ISBN-10: 1846287421

ISBN-13: 9781846287428

ISBN-10: 1852338741

ISBN-13: 9781852338749

Designed to be a pragmatic instruction manual on scientific trial administration in those key healing parts, 'Clinical Trials in Rheumatoid Arthritis and Osteoarthritis' is aimed toward primary investigators pharmaceutical physicians and different pharmaceutical employees occupied with the layout, behavior and tracking of those more and more complicated diseases.

In the final numerous years a brand new sessions of biologic brokers have emerged and adjusted the remedy paradigm for sufferers, not just with classically outlined rheumatoid arthritis, but additionally with different comparable ailments corresponding to ankylosing spondylitis and psoriatic arthritis. in addition, osteoarthritis is a tremendous affliction kingdom that's frequently taken care of by means of the rheumatologist, yet is one the place sufferer administration courses are at the moment constrained with a necessity for brand spanking new healing approaches.

In either inflammatory and non-inflammatory arthritic stipulations, scientific trials became either huge and complicated as a result of nature of the illnesses, with ever-challenging new surrogate end-points being hired.

Topics lined during this identify will consequently contain learn layout, scientific endpoints, technical concerns, info assortment, use of centralized scientific photograph interpreting amenities and biochemical marker laboratories, in addition to facts research and destiny treatments. This booklet takes the person during the strategy step by step from begin to end, additionally supplying a history at the regulatory directions, moral implications, endpoints, and present therapies.

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Additional info for Clinical Trials in Rheumatoid Arthritis and Osteoarthritis

Sample text

Mladenovic V, Domljan Z, Rozman B, et al. Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis: results of a randomized, placebocontrolled, phase II study. Arthritis Rheum 1995;38:1595–1603. 34 S. O. Adebajo 151. Emery P, Breedveld FC, Lemmel EM, et al. A comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis. J Rheumatol 2000;39:655–665. 152. Strand V, Tugwell P, Bombardier C, et al. Function and health-related quality of life: results from a randomised controlled trial of leflunomide versus methotrexate or placebo in patients with active rheumatoid arthritis.

In: Paulus HE, Furst DE, Dromgoole SH, eds. Drugs for rheumatic disease. New York: Churchill Livingstone; 1987: 443. 178. Pincus T, O’Dell JR, Kremer JM. Combination therapy with multiple disease-modifying antirheumatic drugs in rheumatoid arthritis: a preventive strategy. Ann Intern Med 1999; 131:768–774. 179. Williams HJ, Ward JR, Reading JC, et al. Comparison of auranofin, methotrexate, and the combination of both in the treatment of rheumatoid arthritis: a controlled clinical trial. Arthritis Rheum 1992;35:259–269.

29. Eccles M, Freemantle N, Mason J, for the North of England Non-Steroidal AntiInflammatory Drug Guideline Development Group. North of England Evidence Based Guideline Development Project: summary guideline for non-steroidal antiinflammatory drugs versus basic analgesia in treating the pain of degenerative arthritis. BMJ 1998;317:526–30. 28 S. O. Adebajo 30. Guidance on the use of cyclo-oxygenase (Cox) II selective inhibitors,celecoxib, rofecoxib, meloxicam and etodolac for osteoarthritis and rheumatoid arthritis.

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Clinical Trials in Rheumatoid Arthritis and Osteoarthritis by David M. Reid (auth.), David M. Reid MBChB, MD, FRCP, Colin G. Miller BSc, PhD, FICR (eds.)

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