By Timothy GK Mant, Lionel D Lewis, James M Ritter, Albert Ferro
So that you imagine you might have a deal with on healing administration? How medicines paintings and engage with one another, how the physique handles them and the way medicines are assessed? This self-assessment quantity enables you to examine, revise and try out your self on all elements of scientific pharmacology and therapeutics. 4 various query varieties are supplied to check your wisdom during this vital zone - a number of selection questions, prolonged matching questions, better of fives and problem-solving questions. specified explanatory solutions ascertain this publication solves your queries in addition to delivering crucial revision for these all-important assessments. attempt your wisdom with medical Pharmacology and Therapeutics: Questions for Self overview and never basically enhance your examination procedure yet turn into a greater prescriber.
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Extra resources for Clinical Pharmacology and THerapeutics: Questions for Self Assessment, 3rd edition
Insomnia occurs in some patients on SSRIs Clozapine is an ‘atypical antipsychotic’. The term is used imprecisely but generally covers those antipsychotic drugs whose principal pharmacological effect is not D2 blockade and are rarely associated with extrapyramidal side-effects – Neutropenia or agranulocytosis develops in up to 3 per cent of patients taking clozapine for 1 year. Although dystonias and tardive dyskinesias are rare, clozapine is associated with fits in 3–4 per cent of patients and postural hypotension (particularly after the first dose) 57 58 CHAPTER 2 NERVOUS SYSTEM 99 a) b) c) d) e) True True True True True Tricyclic antidepressant overdoses are commonly fatal.
Amphetamine and cocaine raise synaptic NA and alter mood but are not antidepressant 97 a) b) c) d) e) True True True True True See Textbook of Clinical Pharmacology and Therapeutics, Chapter 20. Although clinical experience is most extensive with the tricyclic antidepressants, the side-effect profile of selective serotonin reuptake inhibitors (SSRIs) is usually less troublesome and these drugs are safer in overdose 98 a) b) c) d) e) True True False False False The less sedative tricyclic and related antidepressants include desipramine, imipramine, lofepramine and nortriptyline.
2 D Osteoporosis is an important adverse effect with chronic use of prednisolone and all other glucocorticosteroids (diabetes is another). 3 C Myositis is a dose-related adverse effect associated with statins and fibrates. 4 F SLE-like syndrome is associated with isoniazid, procainamide, hydralazine, chlorpromazine and anticonvulsants. It resembles SLE together with a positive antinuclear factor test. It is dose related. These drugs may act as haptens, combining with DNA and forming antigens. The symptoms resolve (sometimes slowly) on drug withdrawal.
Clinical Pharmacology and THerapeutics: Questions for Self Assessment, 3rd edition by Timothy GK Mant, Lionel D Lewis, James M Ritter, Albert Ferro