Download PDF by Thomas Boll, Brenda K. Bryant: Clinical Neuropsychology and Brain Function: Research,

By Thomas Boll, Brenda K. Bryant

ISBN-10: 1557980381

ISBN-13: 9781557980380

This paintings involves chapters at the growth of neuropsychological examine written through acknowledged psychologists. They file on a vast diversity of themes, addressing easy and utilized matters within the box. Empirical and theoretical advances in our wisdom of mind functionality are explored.

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Additional resources for Clinical Neuropsychology and Brain Function: Research, Measurement, and Practice

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In contrast, Figure 6 shows what happens after PP or N/C rats have received bilateral injury to the frontal cortex and are tested for retention of the learned alternation. Although both groups were impaired in comparison to intact PP or N/C controls, the N/C female rats with frontal lesions were extremely impaired with respect to their PP counterparts. After all behavioral testing had been completed, we removed and examined the brains to see if we could detect any morphological differences resulting from the manipulations we had made.

We began our initial series of investigations using direct, intracerebral injections of nerve growth factor (NGF) into the site of the injury itself (see Stein, 1981, for more detailed review). NGF was one of the first trophic (growth and survival-promoting) substances to be identified by Levi-Montalcini and her colleagues (Levi-Montalcini & Callissano, 1979), so it was logical to see if it would have ameliorative effects when injected directly into the brain. These early experiments met with some degree of incredulity because only 10 years ago, it was thought that NGF would have no central nervous system effects, because attempts to localize receptors for NGF in brain tissue had been unsuccessful, even though Bjorklund and his colleagues (Bjorklund & Stenevi, 1972) were the first to show that NGF injections into the brain could cause sprouting of noradrenergic fibers.

STEIN release of neurotrophic or neuronal survival factors at the site of the injury? We reasoned that the most direct examination of whether the transplants are necessary to maintain functional recovery, would be to remove them after observing an initial effect and then retest the subjects on a new task. This experiment essentially consisted of four groups of adult, male animals. Three of the groups (10 rats per group) received bilateral removals of the medial frontal cortex and one served as a sham-operated control.

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Clinical Neuropsychology and Brain Function: Research, Measurement, and Practice by Thomas Boll, Brenda K. Bryant


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