By Icon Health Publications
It is a 3-in-1 reference publication. It supplies an entire scientific dictionary overlaying enormous quantities of phrases and expressions with regards to cholestasis. It additionally provides wide lists of bibliographic citations. eventually, it presents details to clients on easy methods to replace their wisdom utilizing a number of net assets. The publication is designed for physicians, clinical scholars getting ready for Board examinations, clinical researchers, and sufferers who are looking to get to grips with learn devoted to cholestasis. in case your time is efficacious, this booklet is for you. First, you won't waste time looking out the web whereas lacking loads of appropriate details. moment, the e-book additionally saves you time indexing and defining entries. eventually, you won't waste money and time printing countless numbers of websites.
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Additional info for Cholestasis - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
These studies should substantially increase out knowledge of this important transport system which plays a critical role in numerous physiological processes and in the etiology of several major diseases. e. impairment in bile formation and/or bile flow. The current award was used to isolate a gene which, when mutated is responsible for two forms of inherited cholestasis, benign recurrent intrahepatic cholestasis (BRIC) and progressive familial intrahepatic cholestasis, type 1 (PFIC1). The main goal of the renewal will be to characterize the function of this gene (termed FIC1) by a variety of in vitro and in vivo experiments.
Investigate common regulatory pathways of hepatobiliary transporter genes. The limited availability of effective agents to treat cholestatic diseases detailed explorations into avenues of research that could impact upon the design and use of novel therapeutics. , bile acids or nuclear hormone receptor ligands) adapted towards ameliorating the pathogenesis of cholestasis. ; Associate Professor of Pediatrics; Pediatrics; Mount Sinai School of Medicine of Nyu of New York University New York, Ny 10029 Timing: Fiscal Year 2003; Project Start 30-SEP-1997; Project End 31-MAR-2007 Summary: (provided by applicant): The apical sodium-dependent bile acid transporter (ASBT) is the major carrier protein involved in intestinal reclamation of bile salts.
In the rat ileum, ASBT undergoes a biphasic pattern of developmental expression. Bile acid responsiveness of ASBT is species specific. ASBT is down regulated in the ileitis and up regulated by corticosteroids. Adaptation by ASBT after intestinal resection is dependent upon the length of residual ileum. These changes in ASBT expression are controlled at the level of transcription and mRNA stability. The rat, mouse, and human ASBT promoters have been cloned in my laboratory. HNF1alpha, AP-1 and LRH-1 are critical elements in the transcriptional regulation of ASBT.
Cholestasis - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by Icon Health Publications