Download e-book for iPad: Biosynthetic Products for Cancer Chemotherapy: Volume 1 by George Pettit

By George Pettit

ISBN-10: 1468472305

ISBN-13: 9781468472301

ISBN-10: 1468472321

ISBN-13: 9781468472325

Cancer exacts a really harmful toll at the world's human populations. lately we've got often heard the expression "war on cancer," yet in comparison to the carnage inflicted by way of melanoma, our medical and clinical efforts, so far, would appear extra like a minor skirmish. a few comprehension of the melanoma challenge could be acquired from a glance on the present and projected casualty record for the USA. during this state, approximately 700,000 new situations of melanoma might be clinically determined in 1976 and over 1 million identified circumstances will remain handled. Over 400,000 of those sufferers will die from melanoma in our bicentennial 12 months. With the prevalence of melanoma within the usa expanding to 5.2% in 1975, in comparison to the 1.1 % every year cost skilled for many years, Dr. F. J. Rauscher, Jr.,338 Director of the nationwide melanoma Institute, has anticipated that greater than 10 million humans can be lower than remedy for melanoma and approximately four million will expire from melanoma during this decade. At that price, melanoma will look in approximately of 3 households and the required treatment will expense a few $15-20 billion in line with 12 months. therefore except tools for the remedy and regulate of melanoma are markedly more advantageous, approximately fifty three million americans now alive will finally be melanoma sufferers. Unfor­ tunately the main different types of human melanoma are nonetheless past healing care through surgical and radiological recommendations and thanks to the paucity of at the moment on hand melanoma chemotherapeutic medicines with healing potential.

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Extra resources for Biosynthetic Products for Cancer Chemotherapy: Volume 1

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91 describe the use of plant materials for afflictions assumed to be cancer. , but these materials were probably well known much earlier. Indeed some of this information still forms an integral part of traditional Chinese medical treatment, and a variety of plant extracts are currently in use as supportive measures for contemporary cancer treatment. S. Academy of Sciences medical and pharmacology delegation to the People's Republic of China in 1974, this writer was pleased to see that quotation prominently displayed in the Peking Institute of Materia Medica, where new cancer chemotherapeutic agents are being developed.

In the mid-1960's isolation contracts were awarded to Wall (Research Triangle Institute) and Caldwell. In recent years the latter program has been managed by Cole. 2oo Several years ago, National Cancer Institute laboratories for the plant program were established with Farnsworth at the University of Illinois. A very enlightening summary of the screening procedures and advances in this program to about 1968 has been prepared by Hartwell and Abbott. 145 Additionally, a Naturally Occu"ing Antineoplastic and Cytotoxic Agents ss considerable number of governmental, university, and private laboratories all over the world are now collaborating with the National Cancer Institute's natural products program on an informal or NIH grant basis.

Similarly Kupchan, then at the University of Wisconsin, and Cava, then at Ohio State University, expressed an interest in beginning chemical studies of other plant families. 350 In the summer of 1957, Hartwell transferred to the CCNSC staff to supervise the natural products programs. The search for plant antineoplastic agents then began in earnest, and some 600 extracts from plants collected in the western 54 Chapter 2 hemisphere and Africa by the Eastern Utilization Research and Development Division of the USDA (during their search for sapogenin steroid precursors) were screened along with several hundred more sent by Caldwell at the University of Arizona.

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