Biochemical and Pharmacological Roles of Adenosylmethionine - download pdf or read online

By Vincenzo Zappia, Earl Usdin and Francesco Salvatore (Eds.)

ISBN-10: 0080249299

ISBN-13: 9780080249292

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Read or Download Biochemical and Pharmacological Roles of Adenosylmethionine and the Central Nervous System. Proceedings of an International Round Table on Adenosylmethionine and the Central Nervous System, Naples, Italy, May 1978 PDF

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Extra resources for Biochemical and Pharmacological Roles of Adenosylmethionine and the Central Nervous System. Proceedings of an International Round Table on Adenosylmethionine and the Central Nervous System, Naples, Italy, May 1978

Example text

J. Mason Biological methyl a) donor^. NH2 ^ Ν CH2S*CH2CH2CWOOH HO OH S-adenosyl methionine COOH »» o C H , NH-^P^SVcONHCH CH¿OOH N^-methyl tetrahydrofolic acid Fig. 1. Comparison of the structures of the biological methyl donors (a) SAM and (b) N^-methyltetrahydrofolate (CH3FH4) able uptake process with a Michaelis constant for transport of 18 nM (3). It has been suggested that the requirement for uptake of the reduced form of folates, maintained even in folate-deficiency states (4), is essential because brain tissue lacks dihydrofolate reductase activity (5).

Life Sei. 20, 375 (1977). 11. C. R. Aust. J. Biol. Sei. 27, 465 (1977). 12. N. , Biochemistry 12, 4670 (1973). 13. E. , Biochem. J. 115, 241 (1969). 14. J. , Anal. Biochem. 6, 289 (1963). 15. J. , J. Neurochem. 13, 769 (1966). 16. K. , Anal. Biochem. 15, 323 (1966). 17. K. , Biochem. J. 102, 959 (1967). 18. , Anal. Biochem. 68, 522 (1975). 19. O 20. , Biochim. Biophys. Acta 428, 56 (1976). 21. , Vunnam, C R . , Neurochem. Res. 2, 27 (1977). 22. , in Enzyme Handbook, Supplement I Springer-Verlag, Berlin-Heidel­ berg-New York, 168 (1974).

Jones and Carnegie found no evidence for the existence of two enzymes specific for the methylation of myelin protein and histone (11), but Miyake reported two forms of methylases from rat brain, one for myelin basic protein and the other for histone (12). The myelin protein methylating activity in the cell sap fraction was shown to increase during myélination, while histone methylase from the nuclear fraction was highest at birth with no correlation with the process of myelination. (13). Β. Encephalitogenic Myelin Basic Protein as a Endogenous Substrate The first evidence that one of the endogenous substrates for protein methylase I in the rat brain is the encephalitogenic basic protein of myelin sheath came from the sequence study of the protein.

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Biochemical and Pharmacological Roles of Adenosylmethionine and the Central Nervous System. Proceedings of an International Round Table on Adenosylmethionine and the Central Nervous System, Naples, Italy, May 1978 by Vincenzo Zappia, Earl Usdin and Francesco Salvatore (Eds.)


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